Saturday, November 12, 2016

Literature Review



HLTH 634
Immunization, A Comprehensive Review of the Literature.

Micaiah A. Herndon
11/13/2016





 Introduction:
The introduction and widespread use of vaccines have profoundly affected the occurrence of several infectious diseases, small pox was eradicated from the world, and polio is on the verge of eradication.  Recently, there has been an increase of parents in the industrialized world participating in the anti-vaccination, or “anti-vax”, movement.  The main theoretical structures of anti-vaccination ideology in the 19th and 20th centuries are: vaccines cause idiopathic illness; opponents against vaccines accused vaccine partisans to be afraid of the “search after truth,” they fear unveiling errors; the vaccination law not only insults every subject of the realm, but also it insults every human being; vaccine immunity is temporary; an alternative healthy lifestyle, personal hygiene and diet stop diseases.1
Vaccination is one of the most effective public health intervention methods to prevent the spread of communicable disease, so why are parents refusing to immunize their children?  Over the past decade there have been false claims that certain vaccinations, specifically the MMR (measles, mumps, and rubella) vaccine caused autism.  Though many studies have discounted these claims, many parents still believe that vaccinations will cause more harm than good, herd immunity can protect their child if they refuse vaccination, and change in lifestyle is better at preventing the onset of disease than vaccination.2
Websites opposing vaccination are prevalent on the Internet.  Furthermore, a new postmodern paradigm of healthcare has emerged, where power has shifted from doctors to patients, the legitimacy of science is questioned, and expertise is redefined.  Together this has created an environment where anti-vaccine activists are able to effectively spread their messages.3 An intervention program is necessary to education parents of the importance of immunization in conjunction with other positive health behaviors.  I propose establishing an informative discussion based website that fact check anti-vaccination, commonly known as anti-vaxing, rhetoric and provide answers to questions about immunization.  Heard immunity and community vaccination efforts are imperative to prevention and control of preventable disease. 
Evaluation of past and current literature on immunization trends, the increased use of the Internet by patients, and any relevant intervention programs was conducted.   The articles that selected for review were peer-reviewed and collected using PubMed search engine.  Articles published prior to 2011 were removed from the sample.  All articles containing data collected and or assessing immunization or anti-immunization practices outside of the United States were excluded.  Twenty articles were assessed however only ten were used for the nature of this literature review. 

Body of Evidence:
Various article styles were used for data collection and analysis to include reviews, policy papers, and theoretical articles to understand anti-vaxing and recent influx of its practice.  Articles assessed review the recent surge in anti-vaxing, trends in contagious diseases in the United States from 1888-2013, economic factors of immunization, herd immunity, and the correlation between positive health behaviors and disease acquisition.  Furthermore, assessment of vaccination mandates in the United States, immunization trends in the United States, health provider recommended immunization schedules, and the success of national immunization efforts. 
Why is there a growth in the number of parents choosing not to have their children vaccinated? Kata A. attributes decreasing vaccination practices to an increase in anti-vaxing rhetoric on social media, noting the increase of parents researching information about immunization and the anti-vaxing movement.3 Tafuri S et al. argue that doctors and HCWs constantly have to face parents and patients who search information about vaccination. A lot of these people have previously found data about vaccinations from a lot of sources, such as opinion papers, social media or on anti-waxing websites.  It is important now more than ever for public health officials to increase education efforts and utilize modern methods of education to include social media and the internet. Moreover, doctors and HWCs need to have updated knowledge about the vaccinations and are responsible for educating general public on immunizations and their benefits.1
As with any medication, there are risks associated with immunization.  The US government established the National Vaccine Injury Compensation Program (VICP) to implement controls over immunization and the consequences thereof.  It acknowledges that vaccines, as with any medication, are not without risk to the patient, that vaccines, unlike other medications, are a medical intervention generally given to healthy individuals, and that vaccination has benefits beyond the individual by significantly benefitting the public health through creation of herd immunity, the VICP was established to shift the monetary costs of vaccine injuries away from vaccine recipients and manufacturers.4 
The fear of negative side effects is especially significant among parents of children with autism spectrum disorder (ASD).  As a result, parents are becoming more inquisitive about vaccination processes and are extremely concerned about their outcomes.  Comparably, parents of teens are hesitant and refusing to have their teens vaccinated.   According to Darden PM et al., the most frequent reasons for not vaccinating were the same for Tdap/Td and MCV4, including “Not recommended” and “Not needed or not necessary.” For HPV, the most frequent reasons included those for the other vaccines as well as 4 others, including “Not sexually active” and “Safety concerns/Side effects.”5,6
There are recommendations and regulations in place to ensure that infants and young children are vaccinated in the United States, these rules have significantly improved the overall health and decrease childhood morbidity rates. Ventola et al. notes that the incidence, prevalence, morbidity, and mortality of many communicable diseases have significantly decreased in Western countries largely because of national immunization strategies aimed at infants and children.  It has been estimated that for each U.S. birth cohort receiving recommended childhood immunizations, around 20 million illnesses and more than 40,000 deaths are prevented, resulting in $70 billion in savings.2 Analyses conducted by Zhou et al. showed that routine childhood immunization among members of the 2009 US birth cohort will prevent 42 000 early deaths and 20 million cases of disease, with net savings of $13.5 billion in direct costs and $68.8 billion in total societal costs, respectively. The direct and societal benefit-cost ratios for routine childhood vaccination with these 9 vaccines were 3.0 and 10.17
From both direct cost and societal perspectives, vaccinating children as recommended with vaccines results in substantial cost savings and has reduced the transmission of certain communicable diseases. Van Panhuis et al. evaluates changes in contagious trends in the United States as a result of immunization practices.  It is concluded that state public health programs — especially vaccination — have led to dramatic declines in the incidence of contagious diseases in the United States over the past century.8Though vaccinations of many preventable diseases are available and being utilized, there is still a rise in some preventable, contagious diseases specifically pertussis.  Van Panhuis et al. accredit this to the lack of follow-up and booster vaccine practices.  It is important to note that in addition to individuals failing to continue receipt of immunization after childhood, increases in the overall incidence of contagious diseases is a result of the perception that the risk of acquiring a communicable disease is low—low perceived risk of disease at the individual level can lead to lower participation in control programs, with negative consequences for the entire community.8
General immunity to a pathogen in a population through vaccines that protect against transmission and/or protect against disease has benefits and consequences as described by Domenech do Celles M et al.  They determine that the precise nature of vaccine-induced protection is both controversial and consequential. Vaccines that protect against transmissible infection protect those vaccinated directly, but also protect the unvaccinated who benefit from decreased infection risk: so-called herd immunity. In contrast, vaccines that protect against disease but not transmission benefit only the vaccinated. Although experimental evidence on the transmission impacts of pertussis vaccination is lacking, available incidence data provide evidence for vaccine-induced herd immunity.9 There is no denying the benefits of vaccination, however it is important to note that herd immunity perpetuates false indications of disease and the risk of acquiring certain disease.   Herd immunity has and will continue to influence parents decision to vaccinate their children causing vaccination rates to drop, substantially causing herd immunity to dip below healthy “safety thresholds.”.10
Despite the benefits of herd immunization, many parents chose to refrain or are hesitant about vaccinating their children.  There are concerns about side effects, fears of autism, moral and religious reasons but more often than not, the reason is lack of accurate information regarding immunization.  To improve compliance, the CDC’s Task Force on Community Prevention Services has identified three categories for interventions to overcome vaccine noncompliance: increasing community demand for vaccination, enhancing access to vaccination services, and provider-based interventions.2 These in addition to education will repair herd immunity safety thresholds, and prevent disease.
Summary and Conclusions
In conclusion, it is clear that immunization is an effective way to reduce/eradicate disease.  However, despite the effectiveness of vaccines and the importance of herd immunity, there has been a growing trend of parents choosing the forgo or delay vaccinations for their children.  A large percentage of parents deciding not to vaccinate are making their choices based on false information most of which read on the internet.  The proposed forum style website will be run by public health officials.  It will offer accurate and honest answers to questions about immunization.  It will have health provider information, national immunization trends reporting, epidemics/outbreaks of diseases, and clinics where free or low cost immunizations can be received. 
More research is required to assess the benefits of increasing parental education.  It is unclear if parents will choose to vaccinate their children if they are explained the benefits of the public health practice. 

References:
See reference page.

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